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SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.5
USERS' SCORE
Good
Based on 1 Reviews
8.3
Supplement Facts
Serving Size: 1 vegan softgel
Amount Per Serving
%DV
Calories
5
_
Total Fat
0.5 g
<1%‡
Microalgae Oil (40% DHA)which typically provides:
500 mg
*
DHA (Docosahexaenoic Acid) [Ω-3]
200 mg
*
Top Medical Research Studies
8
DHA may reduce blood clots
Potential Benefits of Omega-3 Polyunsaturated Fatty Acids (N3PUFAs) on Cardiovascular Health Associated with COVID-19: An Update for 2023.
Relevant to cardiovascular health
We delved into the benefits of docosahexaenoic acid (DHA) in relation to blood clotting, especially in the context of cardiovascular health and COVID-19. DHA, a form of omega-3 fatty acid, shows promise in influencing how our body's clotting mechanism works. By integrating into cell membranes, DHA helps reduce inflammation and support overall epithelial function.
Studies indicate a positive link between increased DHA intake and lower risks of thrombotic outcomes, suggesting that it may be beneficial for those at risk of blood clots. The research highlights that both DHA and its counterpart, eicosapentaenoic acid (EPA), play a role in creating bioactive compounds that support cardiovascular health.
Given its safety profile, DHA emerges as a potential adjunctive treatment for individuals vulnerable to cardiovascular issues due to COVID-19. We also consider the optimal forms and dosages for maximum effectiveness, showing how accessible nutrition can aid in maintaining better heart health.
Studies indicate a positive link between increased DHA intake and lower risks of thrombotic outcomes, suggesting that it may be beneficial for those at risk of blood clots. The research highlights that both DHA and its counterpart, eicosapentaenoic acid (EPA), play a role in creating bioactive compounds that support cardiovascular health.
Given its safety profile, DHA emerges as a potential adjunctive treatment for individuals vulnerable to cardiovascular issues due to COVID-19. We also consider the optimal forms and dosages for maximum effectiveness, showing how accessible nutrition can aid in maintaining better heart health.
Read More
8
DHA reduces blood clotting activity
DHA 12-LOX-derived oxylipins regulate platelet activation and thrombus formation through a PKA-dependent signaling pathway.
Directly examines DHA's effects
We sought to understand how docosahexaenoic acid (DHA), an omega-3 fatty acid, influences blood clotting and platelet activity. To do this, we examined DHA and its oxidized forms, known as oxylipins (11-HDHA and 14-HDHA), to see how they affected platelet function and the formation of blood clots.
The results were promising. We found that DHA and its oxylipins reduced the clustering of human platelets triggered by collagen, a key factor in clot formation. Notably, the oxylipins were particularly effective; they not only limited platelet activation but also decreased the secretion of substances critical for clotting. When we tested these substances in whole blood, we noted a significant reduction in the ability of platelets to adhere to surfaces coated with collagen, which is crucial in the early stages of clot formation.
Interestingly, our findings indicated that while DHA showed some effects, the real benefits seemed to come from the oxylipins, especially 11-HDHA and 14-HDHA. In mice studies, thrombus formation was significantly reduced with these compounds, highlighting their important role in managing platelet activation. We also discovered that these effects were linked to the activation of protein kinase A, a pathway that plays a role in cell signaling.
Overall, our research offers valuable insights into how DHA and its oxidative products can help inhibit harmful clot formation. This could have important implications for utilizing DHA as a treatment strategy in cardiovascular health.
The results were promising. We found that DHA and its oxylipins reduced the clustering of human platelets triggered by collagen, a key factor in clot formation. Notably, the oxylipins were particularly effective; they not only limited platelet activation but also decreased the secretion of substances critical for clotting. When we tested these substances in whole blood, we noted a significant reduction in the ability of platelets to adhere to surfaces coated with collagen, which is crucial in the early stages of clot formation.
Interestingly, our findings indicated that while DHA showed some effects, the real benefits seemed to come from the oxylipins, especially 11-HDHA and 14-HDHA. In mice studies, thrombus formation was significantly reduced with these compounds, highlighting their important role in managing platelet activation. We also discovered that these effects were linked to the activation of protein kinase A, a pathway that plays a role in cell signaling.
Overall, our research offers valuable insights into how DHA and its oxidative products can help inhibit harmful clot formation. This could have important implications for utilizing DHA as a treatment strategy in cardiovascular health.
Read More
8
DHA lowers stroke risk
Omega-3 Fatty Acids and Incident Ischemic Stroke and Its Atherothrombotic and Cardioembolic Subtypes in 3 US Cohorts.
Significant findings on fatty acids
We examined how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, influences the risk of blood clots associated with different types of ischemic strokes. The study analyzed data from three large US cohorts, allowing us to assess the relationship between DHA levels and the occurrence of total ischemic strokes, as well as their subtypes—atherothrombotic and cardioembolic strokes.
Our findings revealed that higher levels of DHA in the bloodstream were associated with a reduced risk of atherothrombotic stroke, which involves large- and small-vessel infarctions. Specifically, participants with the highest DHA levels had a 47% lower risk for this type of stroke compared to those with the lowest levels. On the other hand, docosapentaenoic acid (DPA) showed a protective effect against cardioembolic strokes, reducing the risk by about 42%.
Interestingly, eicosapentaenoic acid did not appear to have a significant impact on the overall risk of ischemic stroke. These results suggest that DHA and DPA may operate through different mechanisms to reduce the risk of blood clots in specific stroke types, highlighting the importance of these omega-3 fatty acids in cardiovascular health.
Overall, our study underscores DHA's beneficial role in stroke prevention, particularly for those at risk of atherothrombotic and cardioembolic strokes.
Our findings revealed that higher levels of DHA in the bloodstream were associated with a reduced risk of atherothrombotic stroke, which involves large- and small-vessel infarctions. Specifically, participants with the highest DHA levels had a 47% lower risk for this type of stroke compared to those with the lowest levels. On the other hand, docosapentaenoic acid (DPA) showed a protective effect against cardioembolic strokes, reducing the risk by about 42%.
Interestingly, eicosapentaenoic acid did not appear to have a significant impact on the overall risk of ischemic stroke. These results suggest that DHA and DPA may operate through different mechanisms to reduce the risk of blood clots in specific stroke types, highlighting the importance of these omega-3 fatty acids in cardiovascular health.
Overall, our study underscores DHA's beneficial role in stroke prevention, particularly for those at risk of atherothrombotic and cardioembolic strokes.
Read More
Most Useful Reviews
6.3
Stable blood coagulation
My mother's blood coagulation function is somewhat poor, and her skin is prone to allergies. I discovered that the EPA component can lead to increased bleeding, hence pregnant women often use algae oil. I decided to try this cost-effective product, and I feel that her blood coagulation function has become much more stable.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.5
8
DHA may reduce blood clots
Potential Benefits of Omega-3 Polyunsaturated Fatty Acids (N3PUFAs) on Cardiovascular Health Associated with COVID-19: An Update for 2023.
Relevant to cardiovascular health
We delved into the benefits of docosahexaenoic acid (DHA) in relation to blood clotting, especially in the context of cardiovascular health and COVID-19. DHA, a form of omega-3 fatty acid, shows promise in influencing how our body's clotting mechanism works. By integrating into cell membranes, DHA helps reduce inflammation and support overall epithelial function.
Studies indicate a positive link between increased DHA intake and lower risks of thrombotic outcomes, suggesting that it may be beneficial for those at risk of blood clots. The research highlights that both DHA and its counterpart, eicosapentaenoic acid (EPA), play a role in creating bioactive compounds that support cardiovascular health.
Given its safety profile, DHA emerges as a potential adjunctive treatment for individuals vulnerable to cardiovascular issues due to COVID-19. We also consider the optimal forms and dosages for maximum effectiveness, showing how accessible nutrition can aid in maintaining better heart health.
Studies indicate a positive link between increased DHA intake and lower risks of thrombotic outcomes, suggesting that it may be beneficial for those at risk of blood clots. The research highlights that both DHA and its counterpart, eicosapentaenoic acid (EPA), play a role in creating bioactive compounds that support cardiovascular health.
Given its safety profile, DHA emerges as a potential adjunctive treatment for individuals vulnerable to cardiovascular issues due to COVID-19. We also consider the optimal forms and dosages for maximum effectiveness, showing how accessible nutrition can aid in maintaining better heart health.
Read More
8
DHA reduces blood clotting activity
DHA 12-LOX-derived oxylipins regulate platelet activation and thrombus formation through a PKA-dependent signaling pathway.
Directly examines DHA's effects
We sought to understand how docosahexaenoic acid (DHA), an omega-3 fatty acid, influences blood clotting and platelet activity. To do this, we examined DHA and its oxidized forms, known as oxylipins (11-HDHA and 14-HDHA), to see how they affected platelet function and the formation of blood clots.
The results were promising. We found that DHA and its oxylipins reduced the clustering of human platelets triggered by collagen, a key factor in clot formation. Notably, the oxylipins were particularly effective; they not only limited platelet activation but also decreased the secretion of substances critical for clotting. When we tested these substances in whole blood, we noted a significant reduction in the ability of platelets to adhere to surfaces coated with collagen, which is crucial in the early stages of clot formation.
Interestingly, our findings indicated that while DHA showed some effects, the real benefits seemed to come from the oxylipins, especially 11-HDHA and 14-HDHA. In mice studies, thrombus formation was significantly reduced with these compounds, highlighting their important role in managing platelet activation. We also discovered that these effects were linked to the activation of protein kinase A, a pathway that plays a role in cell signaling.
Overall, our research offers valuable insights into how DHA and its oxidative products can help inhibit harmful clot formation. This could have important implications for utilizing DHA as a treatment strategy in cardiovascular health.
The results were promising. We found that DHA and its oxylipins reduced the clustering of human platelets triggered by collagen, a key factor in clot formation. Notably, the oxylipins were particularly effective; they not only limited platelet activation but also decreased the secretion of substances critical for clotting. When we tested these substances in whole blood, we noted a significant reduction in the ability of platelets to adhere to surfaces coated with collagen, which is crucial in the early stages of clot formation.
Interestingly, our findings indicated that while DHA showed some effects, the real benefits seemed to come from the oxylipins, especially 11-HDHA and 14-HDHA. In mice studies, thrombus formation was significantly reduced with these compounds, highlighting their important role in managing platelet activation. We also discovered that these effects were linked to the activation of protein kinase A, a pathway that plays a role in cell signaling.
Overall, our research offers valuable insights into how DHA and its oxidative products can help inhibit harmful clot formation. This could have important implications for utilizing DHA as a treatment strategy in cardiovascular health.
Read More
8
Fish oil supplementation and bleeding risk
Fish Oil and Perioperative Bleeding.
Relevance score indicates moderate importance
In our evaluation of fish oil supplementation, which includes docosahexaenoic acid (DHA), we sought to understand its impact on blood clotting and perioperative bleeding in patients undergoing surgery. The study involved 1,516 patients who were randomly assigned to receive either fish oil or a placebo before and after their operations.
The main finding revealed that fish oil did not significantly increase the risk of major bleeding compared to the placebo group. In fact, the risk of bleeding, as defined by the Bleeding Academic Research Consortium, was not worse among those taking fish oil. Interestingly, we also observed that participants who had higher levels of DHA showed a substantially lower risk of bleeding.
Additionally, the total amount of blood transfusions needed was lower for the fish oil group. These results suggest that DHA, an essential component of fish oil, may be beneficial in managing bleeding risks during surgery. However, the exact isolated effects of DHA alone on blood clotting require further research since this study evaluated it as part of a mix with eicosapentaenoic acid.
Overall, the findings question the common practice of halting fish oil supplements prior to surgery, showing that they might actually support better outcomes in surgical settings.
The main finding revealed that fish oil did not significantly increase the risk of major bleeding compared to the placebo group. In fact, the risk of bleeding, as defined by the Bleeding Academic Research Consortium, was not worse among those taking fish oil. Interestingly, we also observed that participants who had higher levels of DHA showed a substantially lower risk of bleeding.
Additionally, the total amount of blood transfusions needed was lower for the fish oil group. These results suggest that DHA, an essential component of fish oil, may be beneficial in managing bleeding risks during surgery. However, the exact isolated effects of DHA alone on blood clotting require further research since this study evaluated it as part of a mix with eicosapentaenoic acid.
Overall, the findings question the common practice of halting fish oil supplements prior to surgery, showing that they might actually support better outcomes in surgical settings.
Read More
8
DHA lowers stroke risk
Omega-3 Fatty Acids and Incident Ischemic Stroke and Its Atherothrombotic and Cardioembolic Subtypes in 3 US Cohorts.
Significant findings on fatty acids
We examined how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, influences the risk of blood clots associated with different types of ischemic strokes. The study analyzed data from three large US cohorts, allowing us to assess the relationship between DHA levels and the occurrence of total ischemic strokes, as well as their subtypes—atherothrombotic and cardioembolic strokes.
Our findings revealed that higher levels of DHA in the bloodstream were associated with a reduced risk of atherothrombotic stroke, which involves large- and small-vessel infarctions. Specifically, participants with the highest DHA levels had a 47% lower risk for this type of stroke compared to those with the lowest levels. On the other hand, docosapentaenoic acid (DPA) showed a protective effect against cardioembolic strokes, reducing the risk by about 42%.
Interestingly, eicosapentaenoic acid did not appear to have a significant impact on the overall risk of ischemic stroke. These results suggest that DHA and DPA may operate through different mechanisms to reduce the risk of blood clots in specific stroke types, highlighting the importance of these omega-3 fatty acids in cardiovascular health.
Overall, our study underscores DHA's beneficial role in stroke prevention, particularly for those at risk of atherothrombotic and cardioembolic strokes.
Our findings revealed that higher levels of DHA in the bloodstream were associated with a reduced risk of atherothrombotic stroke, which involves large- and small-vessel infarctions. Specifically, participants with the highest DHA levels had a 47% lower risk for this type of stroke compared to those with the lowest levels. On the other hand, docosapentaenoic acid (DPA) showed a protective effect against cardioembolic strokes, reducing the risk by about 42%.
Interestingly, eicosapentaenoic acid did not appear to have a significant impact on the overall risk of ischemic stroke. These results suggest that DHA and DPA may operate through different mechanisms to reduce the risk of blood clots in specific stroke types, highlighting the importance of these omega-3 fatty acids in cardiovascular health.
Overall, our study underscores DHA's beneficial role in stroke prevention, particularly for those at risk of atherothrombotic and cardioembolic strokes.
Read More
8
DHA aids SPM restoration
Specialized proresolving lipid mediators in patients with coronary artery disease and their potential for clot remodeling.
Limited clarity on isolated effects
We explored how docosahexaenoic acid (DHA), specifically in the form of Lovaza, affects blood clot remodeling in patients with coronary artery disease (CAD). In this study, six individuals with stable CAD were split into two groups: one received daily doses of Lovaza for a year, while the other did not.
Interestingly, we found that patients not on Lovaza showed a complete lack of certain important specialized proresolving lipid mediators (SPMs) that help manage inflammation, specifically resolvin D1, RvD2, RvD3, RvD5, and resolvin E1—all of which are typically present in healthy individuals.
On the other hand, those treated with Lovaza restored some of these SPMs and exhibited higher levels of others that facilitate the removal of blood clots by macrophages. This suggests that DHA can indeed bolster the body's ability to resolve inflammation and aid in the phagocytosis of clots.
However, since the study's sample size was small and involved a combination of treatments, it's hard to draw definitive conclusions about DHA's isolated impact on clot remodeling alone.
Interestingly, we found that patients not on Lovaza showed a complete lack of certain important specialized proresolving lipid mediators (SPMs) that help manage inflammation, specifically resolvin D1, RvD2, RvD3, RvD5, and resolvin E1—all of which are typically present in healthy individuals.
On the other hand, those treated with Lovaza restored some of these SPMs and exhibited higher levels of others that facilitate the removal of blood clots by macrophages. This suggests that DHA can indeed bolster the body's ability to resolve inflammation and aid in the phagocytosis of clots.
However, since the study's sample size was small and involved a combination of treatments, it's hard to draw definitive conclusions about DHA's isolated impact on clot remodeling alone.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Reviews
8.3
6.3
Stable blood coagulation
My mother's blood coagulation function is somewhat poor, and her skin is prone to allergies. I discovered that the EPA component can lead to increased bleeding, hence pregnant women often use algae oil. I decided to try this cost-effective product, and I feel that her blood coagulation function has become much more stable.
Read More
